Alignment of these heterogeneous tumor regions with adjacent immunostained sections showed a strong correlation between tumor grade and aberrant Mapk/Erk signaling that differed between Kras;G12D/+RosamG/mG (K), TAp73;∆td/∆tdKrasG12D/+ (TK), and Kras;G12D/+Trp53;R172H/+RosamG/mG (KP-R172H) mouse models. Here, KRAS is linked to neoplasm.