To test functionally the impact of RUFY3 on EL function, we performed Salmonella infection, since ARL8b/PLEKHM2/HOPS- and Rab7/PLEKHM1-dependent EL mobilizations are particularly important for the maturation of Salmonella-containing vacuoles (SCV) and bacterial replication in macrophages42–44. This evidence concerns the gene PLEKHM2 and Salmonella Infections.