Importantly, preceding the phenotype observed with AM, the numbers and proportion of IFN-γ-producing NK cells were significantly augmented 3 days post-infection in rufy3lox/lox-Itgax-cre animals, while levels of CD3 + T cells were reduced, particularly in the effector/memory T cells compartment (TMEM) (Fig. 10f). The gene discussed is IFNG; the disease is infection.