Strikingly, half of the 12 recurrent genes with expression in cardiac progenitor cells in 22q11.2DS-CTD cases were chromatin regulatory genes: NSD1, KAT6A, KMT2D, PHF21A, EP400 and KMT2C, of which some are associated with known syndromes that include CHD, supporting their candidacy (Table 1). This evidence concerns the gene KMT2C and coronary artery disorder.