CHD7 and CHARGE syndrome: EZH2 is a member of the polycomb complex that methylates H3K27 and Ezh2 genetically interacts with Tbx1 for mouse cardiovascular development40, supporting a connection to Tbx1. CHD7 is the gene for CHARGE syndrome and functions as an ATP-dependent chromatin remodeler that interacts with the BAF complex38 as shown in Fig. 7b.