Indeed, transcription factors binding cAMP responsive element (CRE) motif (ATF1 and CREB1) and CRE-like motif (AP1) are enriched in the oncospheres of multiple cancer types (7/11 and 6/11 of cancer types for ATF1/CREB1 and AP1, respectively, Fig. 1b). The gene discussed is FOS; the disease is cancer.