Moreover, ssGSEA analysis with transcription factor gene sets in 1019 human cancer cell lines (The Cancer Cell Line Encyclopedia,51 CCLE dataset) indicates that CRE transcription factor (ATF1 and CREB1) activities are positively correlated with MYC targets, NRF1 targets and stemness scores (Fig. 4j and Supplementary Fig. S6e). The gene discussed is NRF1; the disease is cancer.