Moreover, individual CSCs in SCC (CD44+CD34+ITGA6+), lung cancer (ASCL1+/CGRP+ neuroendocrine cell) and breast cancer (CD44+CD24-, GSE124887) show concurrent activation of stemness genes, nuclear factors and mitochondrial components (Fig. 6j and Supplementary Fig. S9b, c). The gene discussed is CD44; the disease is lung cancer.