Notably, CRE activity (ssGSEA scores of CREB1/ATF1 target gene set) is positively correlated with neural signals in both TCGA (pan-cancer) and METABRIC (breast cancer) datasets (r = 0.4777 and 0.4180 for TCGA and METABRIC, respectively, Fig. 2c). Here, CREB1 is linked to cancer.