CREB1 and cancer: Next, we examined the clinical relevance of CRE activity by examining the prognostic scores of CRE target genes in the PRECOG dataset.36 Core CRE target genes (43 ATF1/CREB1 targets listed in Supplementary Table S2) are associated with adverse prognoses in 12/39 of cancer types, whereas favorable prognoses are observed in 2/39 of the cancer types (Fig. 1i).