Specifically, the top five enriched pathways in the integrated dataset included hypoxia in tCAFs, the EMT pathway and KRAS signalling in mCAFs, IL6-JAK-STAT signalling in iCAFs, allograft rejection in apCAFs, and E2F targets and the G2M checkpoint in dCAFs, all of which overlapped with top enriched pathways in the breast cancer dataset (Fig. 3f). This evidence concerns the gene IL6 and breast cancer.