We previously demonstrated that the largest subgroup, BL1, includes a subset of highly lethal tumors defined by loss of the tumor-suppressor PTEN (Phosphatase And Tensin Homolog; Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and dual-specificity protein phosphatase) plus five specific microRNAs (labeled red in the PTENlow/miRlow row)(Fig. 4c)70,71. The gene discussed is PTEN; the disease is neoplasm.