In all, six of the seven S-drivers (Jup excluded) have known alterations in primary and metastatic breast cancer, highlighting the importance of the oncogenic pathways they induce; JUP/Plakoglobin/gamma-catenin plays a critical role in collective migration of disseminating tumor cells and in breast cancer metastasis, and its expression correlates with decreased distant metastasis-free45 and overall survival (OS; P = 0.0007; Supplementary Fig. S2a). The gene discussed is JUP; the disease is breast carcinoma.