Thus, using the EGAS00001001753 human breast cancer dataset81, the disease specific survival of RBKO-high(i.e. RB-low)/PTEN-low breast cancer samples was significantly (P < 0.0001) lower than RB-high/PTEN-high with HR = 1.78 compared to RB-low vs RB-high (HR = 1.62) or PTEN-low vs PTEN-high (HR = 1.35). This evidence concerns the gene PTEN and breast cancer.