FBXW7-depletion used as control increased primary tumor weight to near significant level (P = 0.062; Fig. 5h); CDC42BPA depletion significantly increased both primary tumor weight (P = 0.0009) and lung metastases (P = 0.045; Fig. 5i; Supplementary Fig. S7f); whereas MTMR3 knockdown mildly but not significantly increased tumor growth (P = 0.26), but robustly induced lung metastases (P = 0.0007; Fig. 5j). Here, FBXW7 is linked to neoplasm.