In Fig. 6e, we show four examples of proteins where we find an association between the plasma levels and disease stage, including (i) CD22 used to identify CLL patients; (ii) galectin 4 (LGALS4) in colorectal cancer patients; (iii) arbhydrolsase domain containing 14B (ABHD14B) in lung cancer patients; and (iv) the ovarian cancer biomarker Progestagen associated endometrial protein (PAEP). This evidence concerns the gene CD22 and B-cell chronic lymphocytic leukemia.