More than 90% of individuals with HNRNPH2-related neurodevelopmental disorder have a nonsynonymous single nucleotide variant within or adjacent to the nuclear localization signal (NLS) of hnRNPH2, with the 2 most common missense variants, R206W and R206Q, located within the NLS. The gene discussed is HNRNPH2; the disease is neurodevelopmental disorder.