HNRNPA1 and frontotemporal dementia: For example, mutations in HNRNPA1 confer risk of developing multiple neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal lobar degeneration, and pathogenic mutations disrupting the NLS of the HNRNPA1 protein result in disrupted nucleocytoplasmic transport and altered RNA granule dynamics (15, 16).