ATP6AP2 and neoplasm: Fig 4D and 4E show an insignificant decrease in PTEN amount but an increase in the staining of both PACE4 and PRR in tumor tissue compared to PIN areas (Fig 4D–4G). Furthermore, analysis of gene expression data from The Cancer Genome Atlas (TCGA) comparing PTEN and PACE4 and PRR mRNA expression show a very similar expression pattern as our TMA analysis when comparing normal and tumor prostate tissue (Fig 4H).