Finally, the addition of tPA to vancomycin + rifampicin did not significantly improve the overall cure rate of the infection on the vascular grafts, as the cure rate in the vancomycin + rifampicin group was 16% vs. 37.5% cure rate in the vancomycin + rifampicin + tPA group (p = 0.25) (Table 2). Here, PLAT is linked to infection.