MFSD2A and metabolic dysfunction-associated steatotic liver disease: Under conditions of overnutrition leading to the development of NAFLD and NASH, the Mfsd2a pathway for uptake of plasma-derived LPCs likely becomes rate limiting for maintaining liver PC levels, a conclusion supported by our lipidomic data showing reduced 18:2 in PC pools, particularly when PC synthesis via the CDP/choline pathway is reduced.