Interestingly, Mfsd2a mRNA expression was induced as early as 2 weeks and significantly elevated at 8 and 16 weeks after NASH diet feeding (Figure 1B), suggesting that LPC transport by Mfsd2a plays a physiological role in the early response to high-fat diet (HFD) challenge. This evidence concerns the gene MFSD2A and metabolic dysfunction-associated steatohepatitis.