The observed exon 5 deletion in EPCAM has not been associated with epigenetic silencing of MSH2, and the monoallelic MUTYH variant is associated with only a modest increase in CRC risk.27 Among the 10 patients with average-onset colon cancer and advanced adenomas, 3 had germline testing data, and 1 had a monoallelic MUTYH variant. The gene discussed is MSH2; the disease is colorectal carcinoma.