In tumor tissue, KRAS and BRAFV600E variant frequencies were similar for patients with early-onset CRC and patients with average-onset CRC, which is consistent with results for next-generation sequencing in a consecutive series of 759 patients with early-onset vs average-onset CRCs, in which their somatic tumor genomes were indistinguishable.8 Here, KRAS is linked to colorectal carcinoma.