LEP and type 2 diabetes mellitus: Adipocytes are mostly localized in the exocrine pancreas and, to a lesser extent, in the endocrine part [29], and they store triglycerides in lipid droplets through the release of adiponectin and leptin [30] Obesity and the accumulation of fat in the pancreas are also related to the development of type 2 diabetes mellitus (T2DM) [31], with intracellular ectopic lipid storage in islet cells.