TARDBP and amyotrophic lateral sclerosis: Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative diseases characterised by the presence within neurons of toxic cytoplasmic inclusions containing an insoluble form of the TAR DNA-binding protein of 43 KDa (TDP-43) and its C-terminal fragments of 35 kDa and 25 kDa (TDP-35 and TDP-25, respectively) (Casarotto et al. 2022).