In detail, the expression level of RIPK1 was dramatically down-regulated both in the CD19+ B-cells of CLL, DLBCL, and FL when compared with that in normal donors, and in contrast, IGSF3 and TGFB1 expression levels were up-regulated (Fig. 1D). Here, TGFB1 is linked to B-cell chronic lymphocytic leukemia.