The vital functions of RIPK1 have been extensively investigated in solid tumors, such as hepatocellular carcinoma, soft-tissue sarcoma, melanoma, cervical Cancer, etc. [7, 15–17] However, whether and how RIPK1 is implicated in hematological malignancies (especially B-cell cancers) is still not fully explored. The gene discussed is RIPK1; the disease is hematologic disorder.