The five associated genes TNFRSF14 (HVEM), TNFRSF4 (OX40), TNFSF4 (OX40L), BTN2A1, and BTN2A2 that were discovered to predict OS time in HCC patients formed the signature that was created by our investigation. This evidence concerns the gene TNFRSF14 and hepatocellular carcinoma.