PTPRO and diabetic kidney disease: The analysis showed that ACTB has direct links with genes related to RhoA signaling pathway (NET1), formation of F-actin-rich structures (RHOJ), axonal cytoskeleton, actin polymerization (DIAPH1, TMSB4X, EEF1A1, ACTG1, RAC1, ACTG1), growth-suppressive and cell death (SUSD6), GTPase and actin bundling protein (EEF1A1), glucose uptake as well as activate the PI3K kinase (RAC1), cell adhesion as well as cell-surface mediated signaling (ITGA6), transports of proteins to the lysosomes (CHAMP1A), diabetic kidney disease (PTPRO) [46–49].