AGER and endothelial dysfunction: The GeneMANIA analysis revealed that genes involved in oxidative stress (HAO1), RhoA signaling pathway (NET1, RHOJ), endothelial dysfunctions (TXNIP), transcription process (HOXB13), inflammation (AGER) neuronal death signaling pathway (CTSE), axonal cytoskeleton, actin polymerization (DIAPH1) and cytoskeleton remodeling (ACTB) were connected in singular network [3–9, 41–45].