Studies have shown that obesity is associated with a decrease in circulating and adipose tissue expression levels of FGF21 and Irisin as well as their specific receptors, β‐Klotho and FGFR1 for FGF21 and ITGA5 for Irisin, respectively.7, 8, 9, 10, 11. This evidence concerns the gene FGF21 and obesity due to melanocortin 4 receptor deficiency.