The telomerase reverse transcriptase (TERT) gene encodes the enzymatic subunit of the telomerase complex.8 In cancer cells, activating mutations in the TERT promoter region can increase TERT protein production and the subsequent activity of telomerase, resulting in increased telomere length.9 Many studies have investigated the regulation of TERT in healthy tissues and its aberrant expression in malignant cells.10-13 In addition, by promoting the epithelial-mesenchymal transition,14TERT promoter mutations can increase PD-L1 expression15 and thus increase response to ICI therapy. The gene discussed is TERT; the disease is cancer.