Further exploration of HNC tumors revealed that oral cavity squamous cell carcinoma (OSCC) tumors (44%, n = 85/192) were associated with higher TERT promoter mutations vs. other HNC subtypes (17%, n = 98/590) (OR = 3.98; 95%CI, 2.74-5.79; Q = .03). Here, TERT is linked to oral cavity squamous cell carcinoma.