CDC42 and cancer: In humans, dysregulated TKs participatein the development of many diseases, including neoplasms, diabetes,and developmental congenital syndromes.4 TKs form a class of oncogenes involved in most forms of human cancer.5,6 These kinases (e.g., EGFR-TK, ABL1, JAK2) are key players in pathwaysinducing many neoplastic changes (e.g., malignant transformation,growth, metastasis) and are preferentially mutated in tumor cells.7−9