DIMT1 and gastric cancer: In recent years, gene knockdown (small interfering RNA, siRNA) or gene overexpression (Construction of lentivirus vectors carrying alphastatin gene) technology has become a specific and powerful tool to turn off or promote the expression of target genes.11-13 In the present work, we used gene overexpression and siRNAs targeting human DIMT1 to increase and reduce the expression of DIMT1 and study the impact of these technologies on cellular proliferation and apoptosis in GC cell lines.