Along this line, we found that the CTCF-binding site is the most enriched motif in SUMO-2/3 bound chromatin regions in AML cells and CUT&RUN experiments with CTCF antibodies confirmed that the co-binding of CTCF and SUMO is highly enriched at promoters and enhancers compared to intergenic regions. The gene discussed is CTCF; the disease is acute myeloid leukemia.