We focused on the NFKB2 gene for several reasons: (i) it is one of the top-DNR-induced gene in HL-60 cells, (ii) its induction by DNR is reduced in the presence of ML-792 in HL-60 cells as well as in primary AML samples and (iii) its promoter region is both bound by CTCF and marked by SUMO and (iv) it plays important roles in the control of both cell survival and inflammation/immunity (66), two of the main gene categories rapidly affected by the DNR treatment. The gene discussed is CTCF; the disease is acute myeloid leukemia.