SIRT1 and steatosis: Recently, we discovered the protective function of myeloid SIRT1 signaling (14, 15) and its negative regulation of canonical inflammasome-pyroptosis in human and murine IRI-OLT (16), while others have shown that hepatocyte SIRT1 deficiency impaired lipid homeostasis/promoted steatosis in mouse livers under high-fat diet (17).