While we investigated the role of TRPV1 in SN neurogenesis and excitation and BCIBP induction, we found that the 4T1 BC progression in tibiae (Fig. 3A and 3B) and metastasis to lung from tibiae (Fig. 3C and 3D) were significantly reduced in the 4T1 BC mice treated with SB366791. This evidence concerns the gene TRPV1 and breast cancer.