Earlier studies described that TRPV1 is expressed in cancers including BC 33, and osteoblasts and osteoclasts 34, raising the argument that the TRPV1 expressed on non-neuronal cells residing in the 4T1 BC microenvironment may play a role in the axogenesis and excitation of SNs and induction of BCIBP as well. The gene discussed is TRPV1; the disease is cancer.