CAMK2G and breast cancer: We verified that TRPV1 on SNs is activated by the 4T1 BC acidic microenvironment by showing increased expression of Ca2+/calmodulin-dependent protein kinase II (CAMKII), a TRPV1 downstream signal molecule 29, in the 50B11 rat immortalized DRG SN cell line 30 that was treated with acidic 4T1 BC CM or hydrochloric acid (pH 6.5) (Fig. 2D).