Single-target IHC revealed that eight RAAAD-P-LTP pathway markers (Dab1, pP85αTyr607, pLIMK1Thr508, pTau, pPSD95Thr19, pDab1Tyr220, ApoE, ApoJ) accumulated within abnormal neurons or within NPs, were higher in MCI and sAD cases than controls, and positively correlated with histological progression or cognitive deficits (Figs 6–8, Ext Fig 6.1). Here, APOE is linked to Cognitive impairment.