Using IHC and MP-IHC for deep phenotyping of ErC in an NFT stage I non-AD case (Fig 5), we observed that Dab1, pLIMK1Thr508, and pPSD95Thr19 tend to accumulate together with pTau within the soma of the same L2 ApoER2-expressing stellate-shaped neurons and pyramidal neurons (Fig 5). The gene discussed is LRP8; the disease is Alzheimer disease.