LRP8 and Alzheimer disease: Apoer2 signaling is critical for brain development, synapse maturation and maintenance as well as function, and inclusion of exon 19 is protective against AD (Beffert et al., 2005; Dumanis et al., 2011; Forster et al., 2010; Niu et al., 2008; Qiu and Weeber, 2007; Strasser et al., 2004; Wasser et al., 2014).