Similarly, previous studies reported the suppressive effects of other RBPs on neurodegeneration, such as hnRNPA2B1 in fragile X ataxia/tremor syndrome (Sofola et al., 2007), and Pur-α and Zfp106 in C9-ALS/FTD (Xu et al., 2013; Celona et al., 2017). Here, ZNF106 is linked to amyotrophic lateral sclerosis.