For example, in myotonic dystrophy type 1, MBNL1 was shown to be sequestered into CUG repeat RNA foci, and overexpression of MBNL1 in a mouse model was found to compensate its functional loss, resulting in the reversal of myotonia (Kanadia et al., 2006). Here, MBNL1 is linked to myotonic dystrophy type 1.