DHX36 and amyotrophic lateral sclerosis: In addition, we also showed that the expression of IGF2BP1, hnRNPA2B1, DHX9, and DHX36 decreased G4C2 repeat RNA expression and suppressed eye degeneration in our C9-ALS/FTD Drosophila model (Figures 1 and 6), likely via the reduction of DPR levels.