However, consistent with the tumour growth phenotype, restoration of CCNB1IP1 expression did not effectively reverse tumour proliferation suppression caused by MYCN silencing, as evidenced by the unchanged Ki67 staining intensity in the shMYCN+CCNB1IP1OE group versus the shMYCN group (Figure 6K). The gene discussed is MYCN; the disease is neoplasm.