As shown in Figure 6G–J, xenografts in the shMYCN group were significantly reduced in size, weight and growth rate compared with the Ctrl group, whereas tumour suppression was not alleviated in the shMYCN+CCNB1IP1 group, even with the rescue of CCNB1IP1 expression. The gene discussed is CCNB1IP1; the disease is neoplasm.