As shown in Figure 6A–F, the elevation of CCNB1IP1 by exogenous overexpression plasmid failed to alleviate the inhibition of cell growth, colony formation, EdU incorporation and tumour sphere formation due to MYCN knockdown, indicating that maintenance of MYCN level is critical for CCNB1IP1 to foster cell growth and proliferation. The gene discussed is MYCN; the disease is neoplasm.