An additive model of risk variant association with systolic BP and hypertension has also been reported,58 with AAs in the 20–29-year age range showing an increase in systolic BP of 0.94±0.44 mm Hg per risk variant copy and 2–5-year decrease in age at diagnosis of hypertension among APOL1 variant allele homozygotes. This evidence concerns the gene APOL1 and hypertensive disorder.