Recently, Wu et al. investigated histopathologic, genetic, and molecular features in six Black patients with COVID-19 infection, AKI, and de novo nephrotic range proteinuria.35 The authors reported an association between collapsing glomerulopathy and G1-/G2-APOL1 genotype, and interestingly, an absence of direct viral infection in the kidneys—contrary to the findings of previous case studies. The gene discussed is APOL1; the disease is viral infectious disease.