IL1RN and neoplasm: The effect of IL-1RA on in vivo tumor growth was evaluated in mice via orthotopic xenografts of OECM-1-luc cells with IL-1RA overexpression or empty vector as a control (Additional file 1: Figure S6A), and the effect of treatment with metformin, cisplatin (also known as CDDP; a chemotherapeutic agent [39]), or a combination of both, was further evaluated (Additional file 1: Figure S6B).