BMPR2 and pulmonary arterial hypertension: Decreased levels of PPARγ result in increased levels of miR-21-5p, which downregulate a broad plethora of targets such as BMPR2, RhoB, PDCD4, SPRY2, PPARα, PTEN, and SATB1, leading to the stimulation of PASMCs and PAECs proliferation, migration, and contraction and ultimately the development of PAH [100, 102, 103].