Multiple germline variants in GATA2 predispose individuals to familial myelodysplastic/acute leukemia syndrome [34, 35], while germline GPC3 variants are observed in Simpson-Golabi-Behmel syndrome, an overgrowth syndrome that increases the risk of developing Wilms tumor, hepatoblastoma, and neuroblastoma [36, 37]. This evidence concerns the gene GPC3 and Nephroblastoma.