KLK3 and Familial prostate cancer: Research is emerging aiming at detecting clinically significant prostate cancer based on the interpretation of a range of these diagnostic indicators, such as PSA, 4Kscore, prostate size, age, clinical history, prostate-specific membrane antigen (PSMA), PET scan (positron emission tomography), and multiparametric MRI (mpMRI) scan (T1, T2 score, DWI score, DCE score, and PIRADS score).