Research is emerging aiming at detecting clinically significant prostate cancer based on the interpretation of a range of these diagnostic indicators, such as PSA, 4Kscore, prostate size, age, clinical history, prostate-specific membrane antigen (PSMA), PET scan (positron emission tomography), and multiparametric MRI (mpMRI) scan (T1, T2 score, DWI score, DCE score, and PIRADS score). Here, KLK3 is linked to prostate carcinoma.