These data, suggesting that RAGE inhibition halts the IR- and IGF-1R-mediated actions, prompted us to test whether the inhibition of RAGE could interfere with the stimulatory signals induced by both IGF-1 and IGF-2, which are known to activate IR and IGF-1R in diverse physio-pathological contexts, including BC cells [28]. The gene discussed is IGF2; the disease is breast cancer.