PDE2A and diabetes mellitus: Some genes where the top CpGs and DMRs were mapped may influence FPG levels or diabetes, such as MZFI, PTPRN2, ASTN2, GRIN1, SLC6A18, and PDE2A. The MZFI gene binds and transactivates L-selectin promoter, which has been proven to be related to disease entities, including T2DM [47].