Our study presents novel somatic alterations in cancer-related genes in HPV-positive PCa, e.g., ATP1A1, DDR2, LMNA, THRAP3, CSF3R, and DICER1. To our knowledge, these mutations have not been previously described in PCa, and DICER1 mutation is of particular interest. This evidence concerns the gene DDR2 and posterior cortical atrophy.