HNRNPLL and neoplasm: Since the RNA expression of HNRNPLL was irrelevant to its protein expression in tumor tissues (r = -0.17, FDR = 0.25; Supplementary Fig. 3g), we hypothesized that circZFR, upregulated in LUAD, might participate in the post-transcriptional regulation of HNRNPLL. Silencing of circZFR in both LUAD cell lines significantly reduced HNRNPLL protein levels without affecting the mRNA expression and vice versa (Fig. 3g, lower panel; Supplementary Fig. 3h, i).