Besides leading to lung disease, nicotine could aggravate the degeneration of blood vessel smooth muscle cells by inducing an inflammatory response (via the mitogenactivated protein kinase pathway) and increasing oxidative stress for NADPH oxidase-1, thereby accelerating arteriosclerosis and plaques instability, which was related to ST-segment elevation myocardial infarction [17–21]. The gene discussed is WEE1; the disease is lung disorder.