Furthermore, increased proportions of CD180-negative B cells correlate with increased renal legions in murine lupus-like nephritis models (Fujita et al. 2012) and CD180-negative SLE B cells are primarily responsible for the production of anti-double stranded DNA autoantibodies (Koarada et al. 1999; Kikuchi et al. 2002). The gene discussed is CD180; the disease is systemic lupus erythematosus.