CD180 appears to be mainly confined to malignancies of the B cell lineage (Valentine et al. 1988; Miyake et al. 1995; Divanovic et al. 2005; Zarember and Godowski 2002; Porakishvili et al. 2005) with only one report on acute myeloid leukemia which demonstrated that CD180 gene expression is high in leukemic stem cells (Saito et al. 2010). The gene discussed is CD180; the disease is acute myeloid leukemia.