RETREG1 and esophageal squamous cell carcinoma: However, the expression of FAM134B has also been shown to be upregulated in esophageal squamous cell carcinoma compared to non-neoplastic tissues, and upregulation of FAM134B in ESCC induced significant cell proliferation and colony formation, and induce wound healing, migration, and invasion capacities of ESCC [14, 15].