Moreover, univariate and multivariate Cox regression analysis revealed that Clinical Stage (HR = 1.320, 95% CI = 1.018–1.711, P = 0.036) and FAM134B expression (HR = 0.646, 95% CI = 0.429–0.973, P = 0.036) were each recognized as independent prognostic factors in HCC (Table 2). The gene discussed is RETREG1; the disease is hepatocellular carcinoma.