RETREG1 and neoplasm: By analyzing a published microarray-based high-throughput assessment, FAM134B was identified to be significantly downregulated in multiple tumor (Supplemental Fig. 1A) and HCC tissues compared with non-tumor tissue (Fig. 1A, TCAG- hepatocellular carcinoma, n = 421, P < 0.001; Supplemental Fig. 1B, E-GEOD-14,520, n = 445; P < 0.001).