Neurotrophins is a prognostic marker for NB development, which are structurally and functionally related growth factors including Nerve Growth Factor (NGF), Brain-derived Neurotrophic Factor (BDNF), NT-3, and NT-4/5, which stimulate the survival, differentiation, and function in neural cells via selective activation of tyrosine kinase receptors (TrkA, TrkB, and TrkC) [5]. Here, BDNF is linked to neuroblastoma.