The BDNF/TrkB signaling pathway plays an important role in the genesis and development of NB, and has attracted the attention of researchers in non-nervous system tumors [33].The subsequent inclusion of more cases would enable statistical analysis of the correlation between the high level of serum BDNF at initial onset and tumor risk, clinical stage, efficacy, and long-term prognosis, providing a new, effective, and feasible recurrence predictor for children with NB. This evidence concerns the gene NTRK2 and nervous system neoplasm.