HP and adenocarcinoma: Consequently, CAF-derived IL-6, which increased level is observed in Hp-AGFs parallelly to TWIST activation in Hp-AGF—reprogrammed gastric epithelial and adenocarcinoma cells [13], promoted stem cell–like properties in HCC cells by activating Notch signaling through the phosphorylation of STAT3 on Tyr705 [332].