CARD8 and gastric cancer: Polymorphisms in genes, which are involved in the signaling cascades via TLR, NLR, apoptosis-associated speck-like protein, and caspase recruitment domain containing protein 8 (CARD8), can modulate the host immune response during Hp infection [114, 369, 371, 380, 400] and increase the risk of GC [114, 380, 400, 402].