The various groups of host receptors are simultaneously engaged in recognition of Hp compounds and the development of GC, e.g., TLRs, nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), dendritic cell–specific intercellular grabbing non-integrin; retinoic acid–inducible gene (RIG)-I-like receptors (RIG-I); and melanoma differentiation–associated protein 5. This evidence concerns the gene HP and gastric cancer.