Consequently, we have shown that gastric epithelial cells as well as gastric and colon adenocarcinoma cells cultured in TGF-β-rich secretome from Hp-activated fibroblasts were characterized by increased expression of OCT4, which decreased significantly after inhibition of TGF-βR1 activity by its antagonist, SB-43152 [12]. Here, TGFB1 is linked to colon adenocarcinoma.