At least 3.5% of patients with life-threatening COVID-19 pneumonia had genetic defects in TLR3- and interferon regulatory factor 7 (IRF7)—dependent induction and amplification of type I IFN. These findings suggest mutations in other type I IFN–related genes in patients with severe COVID-19 (Beccuti et al. 2020). Since this publication in 2020, it has been a fact. The gene discussed is IRF7; the disease is COVID-19.