CXCR5 and epilepsy: 2I) in the knockdown group; however, the opposite was seen in the AAV-CXCR5 group (Fig. 2G, I). Finally, the cumulative seizure time for the final 7 days of video surveillance was selected for statistical analysis. The results showed that knocking down CXCR5 increased the total SE seizure duration (Fig. 2K), whereas overexpressing CXCR5 had the opposite effect (Fig. 2G–K). Overall, the results of both chemically-induced models of epilepsy indicated that CXCR5 can regulate seizures.