For disease-specific iPSCs, it was reported that in teratomas with a homozygous PTCH1 mutation, medulloblastoma-like tissue was larger than in teratomas heterozygous for the PTCH1 mutation, which indicated the importance of PTCH1 in medulloblastoma formation and Hh-related tumors (Ikemoto et al. 2020; Nagao et al. 2022). This evidence concerns the gene PTCH1 and medulloblastoma.