Although varying mechanisms have been proposed for the role of GATA6 in pancreatic cancer, the Collison et al. classification and subsequent molecular studies have demonstrated that GATA6 inhibits de-differentiation of epithelial to mesenchymal transition (EMT), a fundamental step in metastatic spread (Collisson et al. 2011; Martinelli et al. 2017). This evidence concerns the gene GATA6 and familial pancreatic carcinoma.