GSDME and cancer: Cisplatin, an agent for chemotherapy to treat various types of cancer in clinics, causes serious side effects, such as gastrointestinal toxicity and nephrotoxicity.27 GSDME was expressed at higher levels in the small intestine and kidney of mice (Supplementary information, Fig. S6a); we thus investigated the role that mannose could play in normal intestinal and renal epithelial cells.