IL1R2 has been shown to enhance stem cell self-renewal of breast cancer cells through deubiquitination of BMI1 [87], increased angiogenesis, and proliferation by interaction with the transcriptional factor c-Fos in colorectal cancer [88], and elevated ZEB2 expression in prostate cancer leading to augmented migration and invasiveness [89]. Here, BMI1 is linked to colorectal cancer.