MYC and Huntington disease: To that end, we applied a multistepped analysis using Lasso-regulated logistic regression (Fig. 5a), that pinpointed six TFs (CEBPZ, CTCF, E2F1, MYC, NFYB and ETV4) whose activities could significantly explain the dominance of young WT GPCs over both aged HD and aged WT GPCs (Fig. 5e).